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Semaglutide primarily acts as a GLP- 1 agonist, while Tirzepatide combines GLP- 1 and GIP mechanisms, enhancing its effectiveness for weight loss

*Correspondence: Bo Ahrn [email protected] This article was submitted to Molecular and Structural Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Weight regain is possible when stopping GLP-1 medications, as the appetite-suppressing effects diminish

GLP-1 alone is effective for weight loss, but it is especially powerful when combined with a healthy, balanced diet