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In DIO animals, long-term daily administration of this combination therapy, specifically in a stepwise manner, results in reduced energy intake and greater body weight loss over time when compared to chronic mono- and combined-treated groups, without affecting GLP-1 receptor, preproglucagon or amylin-receptor gene expression in the DVC

This study identified IL-4 as a key tumor-derived factor that drives macrophage polarization, particularly promoting the MARCO-expressing macrophage subset in the ovarian tumor microenvironment

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