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101 Therefore, the inhibition of ER stress is also a therapeutic strategy for treating UC by alleviating intestinal inflammation

An increase in oxidative damage in the diabetic kidney may induce apoptosis and contribute to the development of diabetic nephropathy [312, 313, 315]

Thyroid function is associated with insulin resistance not only in clinically diagnosed DM but also in subjects with a normal glucose tolerance [41,42]

Examples are MTHFR variants, which impact folate metabolism and homocysteine, FTO and MC4R, which are associated with weight regulation, CYP19A1, which is involved in aromatase and estrogen balance, ESR1 and ESR2, which are estrogen receptors, and variants in FSHR and LHCGR that alter ovarian response