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Direct comparison is limited because these peptides operate through entirely different mechanisms, target different tissues in research models, and have different molecular characteristics

Its drug price negotiation provisions, which apply to high-expenditure drugs covered by Medicare, have created a new type of LOE event that operates independently of patent expiration

This decentralization has created a patchwork of policies: some states cover GLP-1s for diabetes only, others for both diabetes and obesity, and a few restrict coverage to specific patient populations or BMI thresholds