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8.5 Reimbursement and health technology assessment Reimbursement considerations increasingly influence drug development strategy from early stages ( Conversely, peptides developed solely on the basis of biomarker changes without clear clinical relevance may face reimbursement challenges regardless of regulatory approval ( 8.6 Scientific integrity and responsible framing From a scientific-integrity standpoint, the renewed interest in underexplored peptide systems carries an obligation to avoid overstated claims and selective citation

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Key approved indications include: Type 2 diabetes mellitus management (Mounjaro) Chronic weight management in obesity or overweight with comorbidities (Zepbound) Use as adjunct to lifestyle modification (diet and exercise) It is critical to recognize that tirzepatide has no FDA approval for the treatment, prevention, or management of autoimmune diseases

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