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The kinase Lkb1 mediates glucose homeostasis in liver and therapeutic effects of metformin

37 This can involve adding a small amount of weight, performing more repetitions within the target range (e.g., aiming for 15 reps instead of 12), adding another set, slightly reducing rest time, or moving to a more challenging exercise variation

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A phase I/II trial of dapagliflozin in 38 lupus patients (including with and without lupus nephritis) showed an acceptable safety profile, with no increase in disease activity or proteinuria over the 6 months of the study