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As a key coenzyme in mitochondrial energy metabolism, increased NAD enhances mitochondrial oxidative phosphorylation, promotes triglyceride breakdown in adipocytes, and converts fat into energy for the body, thereby reducing adipose tissue accumulation

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For instance, Vps34-K356/781la enhances the interaction of Vps34 with Beclin1, Atg14L, and UVRAG, which promote autophagic flux and endolysosomal trafficking in skeletal muscle and cancer cells