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It is a historical artefact, not an established dose

J Neurosci 33(24):99579962 Kathrin, Tllner Saskia, Wolf Wolfgang, Lscher Manuela, Gernert (2011) The anticonvulsant response to valproate in kindled rats is correlated with its effect on neuronal firing in the substantia nigra pars reticulata: a new mechanism of pharmacoresistance