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Investigative Ophthalmology & Visual Science , 61 (13), 12

Some individuals report improved energy and motivation as weight decreases and metabolic health improves

Moreover, overproduction of ROS has an impact to enhance the cancer cell proliferation, migration, metastasis, invasiveness and poor prognosis through many cellular mechanisms like matrix degradation, cell-cell contact, cell remodelling, as well as regulation of gene expression [54]

Overall, the above results show that senescent cells display high levels of ROS, increased Fe 2+ and alterations in lipid metabolism that prime them for ferroptosis, a fate prevented by GPX4 upregulation