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J Clin Invest (2004) 113(1):257.10.1172/JCI20660 181 BarbourLAMizanoor RahmanSGurevichILeitnerJWFischerSJRoperMDet alIncreased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess

The mechanisms are complementary rather than redundant, so standard Dihexa doses (0.52mg) remain appropriate when stacking

In our model, we assume a 60 kg individual and a dose of 20mg/kg, which would make that standard dose 1200 mg