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Tirzepatide is not recommended for people with a family history of thyroid tumors or a family history of medullary thyroid carcinoma (MTC) and MEN2 syndrome (multiple endocrine neoplasia type 2 syndrome), as tirzepatide increases the potential risk of developing these tumors in rodents

Their experience suggested that the patchy hypopigmentation tended to resolve after 30-40 doses due to the evolution of a uniform skin-lightening effect Depletion of natural hepatic stores of glutathione: Hypothetically, long-term supplementation with any external synthetic compound may signal the body to stop its own production resulting in dependence on synthetic supplements