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IGFBP-3 plays an anticancer role by exerting cytotoxic effects on cell survival through a mechanism dependent on the interaction between the glycosaminoglycan hyaluronic acid (HA) and CD44

MAPKs are the serine/threonine protein kinases that activate the cellular stress caused by heat shock and mitogen osmotic stress, as well as inflammatory cytokines (such as TNF-, IL-1, and IL-6) [60]

Researchers study it for its role in innate immune defense, epithelial signaling, and host-pathogen interaction throughout the GI tract

N Engl J Med 373(1):1122 Ramesh N, Mortazavi S, Unniappan S (2016) Nesfatin-1 stimulates cholecystokinin and suppresses peptide YY expression and secretion in mice