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15,20 Modafinilwhich is FDA-approved for treatment of narcolepsy, obstructive sleep apnea, and shift work sleep disordercan increase wakefulness in patients with excessive daytime sleepiness and secondary fatigue, but it does not decrease fatigue in patients with CFS

In April 2025, Empower Pharmacy, a large 503B compounding pharmacy in the US, challenged Eli Lillys pharmaceutical exclusivity by filing a petition to invalidate Eli Lillys tirzepatide patent, arguing that the drug is unpatentable due to prior art

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