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As individuals age, the bidirectional communication between muscle and vascular systems becomes compromised, resulting in a reduction of capillary density, a decrease in the bioavailability of endothelial nitric oxide (NO), and an overall decline in muscle perfusionthese elements collectively contribute to the intensification of anabolic resistance and the acceleration of sarcopenic progression (5, 6)

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In clinical practice, inositol supplementsparticularly myo-inositolhave been studied primarily for polycystic ovary syndrome (PCOS), where they may help improve insulin sensitivity and metabolic parameters

The study was conducted between October 2024 and August 2025 and reported following the Reporting of Studies Conducted Using Observational Routinely Collected Health Data for Pharmacoepidemiology (RECORD-PE) statement and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guidance 45