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The aim was to gather research related to the etiology, inducements, pathogenesis, and treatment of migraines, with a particular focus on the roles of oxidative stress and inflammation in migraine and the therapeutic potential of topiramate therein

18 Topically applied recombinant human TRX-1 suppressed the local inflammatory response evidenced by a reduction of cytokines and chemokines, such as TNF-, IL-1, IL-6, CXCL1, and MCP-1 in the dermal tissue