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review at 4 mg, 9 mg, 12 mg Best For Mirrors current Phase 3 maintenance arms Approach Slow titration Duration Add 2-4 weeks per dose step when GI symptoms persist Review Point Each dose step Best For When nausea, vomiting, or diarrhea is hard to tolerate Trial protocols allowed participants to stay at the current dose for an extra 2-4 weeks when GI side effects were significant

These studies indicate that 5-amino-1mq can delay skin fibroblast senescence by regulating NAD+ metabolism, providing a novel intervention target for skin anti-aging research

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doi: 10.1007/BF00197797 123 ParisiK.PoonS.RendaR