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In mice, when scientists blocked 15-PGDH, they saw: Thicker, healthier articular cartilage Existing cartilage cells acting younger Improved joint structure Signs of similar regeneration in human cartilage samples in the lab This is the first time scientists have shown that shutting down one enzyme may restart the bodys natural cartilage repair program

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The expression of HMIT has also been detected in astrocytes and it seems to be localized both in intracellular and plasma membrane, as depicted by immunochemistry [52]