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Nausea occurred in approximately 24-33% of participants across all tirzepatide doses, but it was most common during dose escalation phases and typically resolved within two to three weeks of stabilizing at a new dose

Interestingly, the FAERS signal for tirzepatide is lower than for semaglutide, even though the clinical trial rates are higher

In line with laboratory-controlled studies demonstrating altered food preferences, the reduction in food intake among GLP-1 users is disproportionately associated with decreased consumption of processed foods, while intake of fruits and vegetables has increased overall

Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes