The combination results in three convergent signals: reduced caloric intake (GLP-1/GIP appetite suppression), improved insulin sensitivity (GIP/GLP-1 pancreatic effects), and elevated calorie burn (glucagon thermogenesis)
Increased HIF-1 activity is also observed for other iron chelators, such as salicylaldehyde isonicotinoyl hydrazone (SIH) and deferiprone ( FIGURE 11 Among the DFO analogs are those where the DFO molecule has been attached to various high-molecular weight polymers, including cellulose, dextran, or hydroxyethyl starch
This is because both compounds affect gastrointestinal motility and appetite through their respective mechanisms, and layering them too aggressively creates compounding GI effects that can derail compliance
, 16 , 732-734, Von Wirn, N., Klair, S., Bansal, S., Briat, J.-F., Khodr, H., Shioiri, T., Leigh, R