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It also reduced insulin resistance by influencing PPAR alpha and gamma expression (16) and by modulating phosphorylation status of insulin receptors and downstream signaling molecules (17)

This positions postbiotics as context modulators that complement established lean masspreserving interventions rather than substitutes for them ( Although postbiotics are not expected to exert direct anabolic effects on skeletal muscle, their potential relevance to lean mass preservation lies in indirect metabolic pathways

In placebo-controlled trials with risperidone, aripiprazole, and olanzapine in elderly subjects with dementia, there was a higher incidence of cerebrovascular adverse reactions (cerebrovascular accidents and transient ischemic attacks) including fatalities compared to placebo-treated subjects

SCFAs have protective cardiovascular effects, while TMAO and lipopolysaccharides (LPS) from gut dysbiosis exacerbate cardiovascular diseases by promoting inflammation and endothelial dysfunction [40]