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Considering that mitochondrial dysfunction leads to a decrease in ATP supply and excessive ROS production, which in turn triggers cellular damage, oxidative stress, apoptosis, inflammation, and fibrotic responses, moreover, renal diseases can also affect mitochondrial function through multiple pathways, including mitochondrial bioenergetics, membrane integrity, calcium homeostasis, and mitochondrial dynamics [11]

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33,34 NONPHARMACOLOGIC Exercise and physical therapy are options to decrease pain and improve walking distance in the short term, but there is no robust evidence for these treatments

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