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1 4) Whole-body metabolic programming (preclinical) In diet-induced obesity and metabolic-syndrome models, pharmacologic ERR activation by SLU-PP-332 has been reported to remodel metabolic gene networks in multiple tissues (e.g., muscle, liver) and align physiological readouts with increased energy expenditure and lipid utilizationfindings specific to the research setting

For patients especially the hundreds of millions priced out of these drugs today the next five years represent the best realistic chance in medical history that transformative obesity and diabetes treatment becomes accessible at the population level

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However, its primary mechanism is appetite suppression rather than metabolic acceleration