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In this clinical case, IOC exhibited iron deposition (including intracellular micrometer-size particles), fibrosis, hypertrophy, remodeling of Ca 2+ cycling, metabolic remodeling, and a heightened degree of oxidative stress compared to non-failing control hearts

Its core function is to promote the formation of new connections between neurons by binding to hepatocyte growth factor (HGF) with high affinity and enhancing the activity of its receptor c-Met

doi: 10.1371/journal.pone.0021827 277 ToK.CaoR.YegiazaryanA.OwensJ.NguyenT.SasaniniaK.et al

Clinical evidence for PDRN in skin regeneration is substantial, and it has been used in Korean and Italian dermatology for wound healing, post-procedure recovery, and anti-ageing for over a decade