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The primary mechanisms of action include: Enhanced insulin secretion : GLP-1 receptor agonists stimulate glucose-dependent insulin release from pancreatic beta cells, meaning insulin is released only when blood glucose levels are elevated, reducing hypoglycemia risk when used as monotherapy (though risk increases when combined with insulin or sulfonylureas)

628 -opioid receptor agonis Buprenorphine: Transdermal buprenorphine was evaluated in a randomized, double-blind, parallel-group, placebo-controlled trial

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We identify ADRB2, BCL3, EGR1, FOS, and MAP3K8 not merely as isolated targets but as components of a disease-associated regulatory network that is upregulated in MASLD