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The mechanism does not involve receptor downregulation or tolerance in any known way, but the signal-to-noise ratio is simply too low based on available evidence

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In the case of weight loss, a physician-supervised weight loss program will be the most effective way to lose weight and keep it off long-term

During treatment, close monitoring of clinical, urine volume, and laboratory parameters is recommended to prevent overcorrection, which can lead to osmotic demyelination syndrome (ODS) 10