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For many people, drinking enough water may also help reduce common adjustments such as constipation or mild digestive discomfort , which are sometimes reported during GLP-1 use

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Lancet 390 (10113), 26272642 (2017)

However, doctors may recommend GLP-1 agonists if you: Cannot tolerate metformin Are unable to lower your blood sugar levels with ongoing medications even after three months Experience complications due to other conditions such as heart failure, atherosclerosis or chronic kidney disease Cleveland Clinic reports that doctors may also recommend two GLP-1 agonists, semaglutide and liraglutide, for treating obesity