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Further experimental and clinical trials are now needed to confirm this hypothesis and to clarify the molecular mechanisms underlying hyperhomocysteinemia-induced vascular disease
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Newer, more specific PET tracers, such as those targeting cyclooxygenase enzymes (COX-1/2), monoamine oxidase B (MAO-B), the purinergic P2X7 receptor, colony stimulating factor-1 (CSF-1), 7 nicotinic receptors and cannabinoid 2 receptors and phosphodiesterase 4B (PDE4B) should allow for more precise characterization of neuroimmune signaling [350,351,352]
These encouraging results mean that prospective trials are needed to determine whether GLP-1 receptor agonists can be repurposed as gerotherapeutics, say the authors
