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This is accomplished predominantly by the serotonin reuptake transporter protein (SERT) on the presynaptic membrane, though there is evidence that the plasma membrane monoamine transporter (PMAT) may also contribute
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Other documented findings include a tendency toward IGF-1 receptor desensitization with prolonged, continuous exposure, transient fluid retention in early study phases, and at supraphysiological exposure levels examined in some research acromegaly-like tissue changes
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