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2.1.4 Impaired intestinal and renal excretion Approximately 90% of patients with gout exhibit impaired uric acid excretion, primarily due to reduced renal urate clearance (Nakayama et al., 2023

These microbiota-mediated effects represent a critical pharmacological axis in the therapeutic potential of natural products for GI diseases

As a result, the methylation cycle will be compromised or impaired, along with many other functions that depend on it, including glutathione production

Hormonal and sleep rhythm regulation: Supports hormonal balance, regulates circadian rhythm and improves sleep quality, with beneficial effects on general health and well-being