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Strikingly, estrogen deprivation was shown to be the principal mediator of impaired wound healing in the elderly population when a microarray study revealed that 78% of genes differentially expressed between wounds from young and aged men were estrogen-regulated, while only 3% were related to intrinsic aging (Hardman and Ashcroft, 2008

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Aquat Toxicol 19:131161 Winters MJ, Verweij F, Garofalo E, Ceradini S, McKenzie DJ, Williams MA, Taylor EW, Butler PJ, van der Oost R, Chipman JK (2005) Tissue levels and biomarkers of organic contaminants in feral and caged chub ( Leuciscus cephalus ) from rivers in the West Midlands, UK