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Presently, the precise pathogenesis of hepatic encephalopathy remains incompletely elucidated, with theories encompassing ammonia toxicity, neurotransmitter imbalances, and amino acid perturbations, among which ammonia toxicity serves as a focal point

Because of its dietary origin and the toxicity associated with its depletion, ET may represent a new vitamin whose physiologic roles include antioxidant cytoprotection

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For normally distributed data a mixed linear model (MLM) was used, (as laid out by IBM in their SPSS Statistics guidelines, with mice IDs as subject variable and random effects, sex and APOE genotypes as factors, and age as a covariate