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As a pivotal regulator, NRF2 maintains cellular redox status homeostasis by activating downstream target genes, preventing the accumulation of reactive species

We find that high Li exposure, ferroptosis, and unexplained miscarriage are closely associated and causally regulated, which is dependent on non-canonical MBOAT1 but not classical GPX4

Mass spectra were acquired on a High Resolution Mass Spectrometer Orbitrap, Q-Exactive (Thermo Fisher Scientific) equipped with electrospray ionization (H-ESI-II), coupled to a Liquid Chromatographer Dionex Ultimate 3000 HPLC system (Thermo Fisher Scientific) equipped with a Accucore RP-MS column (50 2.1 mm ID, 2.6 m) (Thermo Scientific)

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