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The therapeutic principle of microneedle delivery of polyphenols is to deliver polyphenols to the skin or tissue through the insertion of the microneedle tip

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Nevertheless, transplacental passage is rapid, and fetal levels approach maternal concentrations within minutes, raising concerns when prolonged infusions are contemplated

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These collectively support youthful, healthy skin and slow the signs of aging

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Finally, in obese diabetic individuals, the GLP-1R/GIPR/GcgR tri-agonist may be the most appropriate option, having the greatest potential to improve metabolism by weight-dependent and -independent mechanisms

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