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We reasoned that if LOH provides a fitness advantage by selective deletion of disadvantageous non-synonymous mutations, we might observe the preferential loss of regions with a higher than the expected number of non-synonymous mutations, which can be estimated from the number of synonymous mutations and human codon usage frequencies (see Supplementary Material)

Regulatory watch Last reviewed Jul 12, 2026 Next review Jul 24, 2026 Evidence snapshot Human trial record: a Phase 1 safety and pharmacokinetics registry entry has no posted efficacy result

Lancet 366 (9490), 10361044

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