should i take glp 1 for weight loss GLP-1 Medications Loss: Semaglutide vs Tirzepatide vs Retat – Revolution Health & Wellness Understanding GLP-1 and Its Role

J Vasc Surg

See also Supplemental Figure 3 and Supplemental Table 2

But heres the quiet detail most people miss: In certain patients, this combination can contribute to high anion gap metabolic acidosis (5-oxoproline accumulation), especially where there are risk factors like sepsis, malnutrition, renal impairment, chronic alcohol use, or prolonged high-dose paracetamol

Hence, in case of persistent albuminuria and/or uncontrolled metabolic risks (i.e., inadequate glycemic control, hypertension, overweight/obesity) on SGLT2i therapy, GLP-1RAs should be considered as the preferential add-on therapy in T2DM patients with chronic kidney disease