l carnitine cycle The involves generation of a long chain acylcarnitine L-Carnitine and acetyl-L-carnitine roles and

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10.1002/adma.200802453 3 BawaP.PillayV.ChoonaraY

Mitochondria have also been identified as a key player in the elimination of ROS

Anti-inflammatory activity The anti-inflammatory effects of Schisandra chinensis lignans are primarily mediated through the inhibition of proinflammatory signaling pathways, including inducible nitric oxide synthase (iNOS) and COX-2, Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-B) and mitogen-activated protein kinases (MAPK), which lead to a reduction in proinflammatory mediators [nitric oxide (NO) and prostaglandin E2 (PGE-2)] and proinflammatory cytokines [tumor necrosis factor alpha (TNF-), IL-6, interferon gamma (INF-), interleukin-1 (IL-1) and monocyte chemoattractant protein-1 (MCP-1)] [8]