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Targeting sterile inflammation for AILI treatment APAP-induced liver injury is characterized by hepatocyte necrosis, which causes release of cellular contents including nuclear DNA fragments [76], high mobility group box-1 protein [6], mitochondrial DNA [76], uric acid [63] and ATP [4]

The higher the ambient levels of insulin, the bigger the degree of NEFAs that penetrate the liver

Supplementation with riboflavin was reported to temporarily slow the disease progression in a patient with the severe encephalomyopathy [155]

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