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This was not attributable to decreased S phase, because these cells had similar BrdU incorporation regardless of the treatment (Extended Data Fig

Dose escalation over 20+ weeks to reach 15 mg

Notably, while GLP-1 can potentially affect glucagon secretion via its stimulatory effect on the -cells in normal physiological conditions, GLP-1 also inhibits glucagon release in type 1 diabetes, thus demonstrating that GLP-1 inhibition of glucagon secretion does not fully depend on the -cell secretome [516]

However, compounded drugs are not FDA-approved and may be associated with higher safety concerns and product quality issues