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A list of candidate biomarkers was determined from the proteins that presented a Welch t-test q- value less than 0.05 (after BenjaminiHochberg correction for multiple testing) and from the top contributors in component 1 and 2 of a sparse partial least square discriminant analysis (sPLS-Da) computed with the Mixomics R package 56

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doi: 10.1007/978-94-007-6889-5_13 21 LinYJiangMChenWZhaoTWeiY

Metformin activates signaling pathways related to mitogen-activated protein kinase (MAPK), which plays a crucial role in determining cellular responses to growth and stress signals (40)