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Abstract Background: Suicide risk is prominent among the problems affecting populations, mainly due to the broad family, psychosocial and economic impact

In the intracellular domain, the sharp kink around the conserved Pro 6.47b -X-X-Gly 6.50b motif in TM6 pivoted the intracellular half of TM6 to move outwards by 18.4 (measured by C carbon of K346 6.35b ), to the same extent as that achieved by orthosteric agonists (Supplementary Fig

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