oxidative stress and glutathione stress, glutathione, CYP2E1 in 1,4-dioxane liver cytotoxicity and genotoxicity: insights from animal models Glutathione (Oxidative Stress and Disease):

When PGH synthase is activated, the peroxidase function of the enzyme generates oxygen radicals that could interact with polyunsaturated fatty acids in the placenta to form lipid peroxides

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They were contacted and were given the Global Response Assessment questionnaire to evaluate the patients perceptions of treatment effectiveness.64 (Peters et al., 2008) See Table 1 for the Global Response Assessment Scale

Doses were inconsistent, side effects showed up more often than expected, and in some cases, the risks were serious enough to outweigh any potential benefits