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Firstly, it directly damages ocular tissues, provoking inflammation and immune cell infiltration ( 2 Oxidative stress in TAO 2.1 Basic concept of oxidative stress Oxidative stress occurs when there is an imbalance between ROS production and the antioxidant defense systems capacity to neutralize them ( Oxidative stress plays an important role in the pathomechanism of TAO

If serious safety issues emerged, trials would be halted immediately (which hasnt happened)

These developments, taken together, represent the most significant structural shift in GLP-1 access in the United States since the drugs were first approved

In a Phase IIb study by Steidle et al