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For decades, sorafenib, a multiple kinase inhibitor, has been the sole approved first-line treatment for advanced HCC despite the fact that it offers only three-month survival benefit over placebo 28

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The significantly reduced CAT activity in the G1 groups serum suggests overwhelming oxidative stress as a result of a diabetic condition, thus, indicating increased production of oxygen-free radicals, which could be linked with persistent hyperglycemia, otherwise known as high blood glucose (Takemoto et al

However, more recent studies have failed to find an inverse relationship between maternal choline intake and risk of NTDs (60-63)