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At 48 weeks, treatment discontinuation due to adverse events was 0% at 1.2 mg and 1.2% at 1.8 mg versus 3.5% on placebo

These improvements can decrease the risk of developing serious conditions such as heart disease, type 2 diabetes, and certain types of cancer

14.4 Cardiovascular Outcomes Trial of RYBELSUS in Adult Patients with Type 2 Diabetes Mellitus and High Risk of Having a Cardiovascular Event Trial 7 [Semaglutide Cardiovascular Outcomes Trial (SOUL), NCT03914326] was a randomized, double-blind, parallel-group, placebo-controlled trial

The GLP-1 receptor appears throughout the brain, pancreas, and gastrointestinal tract, making it one of the most versatile metabolic targets available