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it is a key fibrotic mechanism that plays an important role in kidney disease development [90]

They determined that external Haller indices are highly correlated with the traditional Haller index, but demonstrated the need to determine new threshold values for external Haller indices as the Haller index criteria are not directly applicable to external 3D scanning.[90] They concluded that 3D optical scanning is an attractive, feasible, and promising imaging technique to determine the severity of pectus excavatum without exposure to ionizing radiation, but no evidence was found that supports nor discards the use of 3D scans to determine pectus carinatum severity.[90] Non-operative management: Several non-operative treatments have been proposed for pectus excavatum and carinatum

Davis SP, Landis BJ, Adams ZH, Allen MG, Prausnitz MR

In addition, GSH plays a pivotal role in the pathogenesis of numerous human diseases including cancer and cardio-vascular diseases