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Roche with its 2024 acquisition of Carmot, and Pfizer, following its 2025 acquisition of Metsera, enter obesity and broaden their presence in cardiovascular/metabolic, while other large pharmaceutical companies prepare to follow later in the decade

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( Glycemic Control Compared to maintaining GLP-1RA, both strategies of adding basal insulin (i.e., free-up titration of basal insulin or switching to FRC) effectively decreased HbA1c from baseline to week 26 (free up-titration, WMD 0.71%, 95% CI 1.05 to 0.37