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Since the progression to invasive PDAC is believed to take more than a decade, the follow-up periods in many cohort studies and randomized controlled trials (where it is typically 12 years) are insufficient to understand the long-term effects

adherence and sustainability determine long-term success

272 Notably, exogenous lactate augments H4K12la in microglia, subsequently enhancing PD-1 transcription, microglial proliferation, scar formation, axon regeneration, and locomotor function recovery, thereby facilitating injured spinal cord repair

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