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The phagocytic capacity of macrophages toward ferroptotic tumor cells demonstrates anti-tumor activity, with various immune-stimulatory signals released by ferroptotic tumor cells enhancing phagocytic efficiency ( 6 Iron metabolisms influence on macrophage polarization Macrophages store iron through FT binding, with iron-related gene expression profiles varying across polarization stages

doi: 10.17756/jfcn.2017-045 30

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These complications, therefore, result in a dilemma in the treatment modality among clinicians, especially in elderly patients or in the presence of associated co-morbidities (Salmani et al