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Eur J Clin Invest 22: 283-291, 1992

This peptide can also increase energy in adults, speed up metabolism and offer anti-aging benefits

By age 60, levels drop to approximately 80 ng/mL a 60% decline

The rs4680 single nucleotide polymorphism (SNP) in COMT, which causes a three- to fourfold decrease in the dopamine metabolizing activity of this enzyme (Lachman et al., 1996), increases the risk of psoriasis (Sobolev et al., 2019), although variable changes in COMT levels in response to different treatments suggest increases in systemic or local dopaminergic tone are only a part of the disease process (Souteiro et al., 2013)