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The dosage is escalated by adding 2.5 mg to the existing dosage every 4 weeks

There's no strong theoretical reason to weight angiogenesis more heavily than cell migration (or vice versa) in tissue-repair research both are prerequisites for repair, both contribute distinct mechanisms, and neither obviously dominates the other in published research models

High NNMT expression is closely associated with glucose dysregulation: excessive NNMT activation disrupts nicotinamide metabolism, lowers NAD+ levels, impairs insulin signaling, reduces cellular glucose uptake and utilization, and promotes hyperglycemia and insulin resistance